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Zonisamide
API |
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Haorui supplies high quality Zonisamide API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Zonisamide API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Zonisamide? |
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Zonisamide is used in combination with other medications
to treat seizures in adults with epilepsy. Zonisamide is
in a class of medications called anticonvulsants. It
works by decreasing abnormal excitement in the brain. |
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Zonisamide Drug Interaction |
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Zonisamide and
other carbonic anhydrase inhibitors such as topiramate,
furosemide, and hydrochlorothiazide have been known to
interfere with amobarbital, which has led to inadequate
anesthetization during the Wada test.
Additionally,
the metabolism of zonisamide is inhibited by
ketoconazole, ciclosporin, miconazole, fluconazole and
carbamazepine in descending order. |
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Zonisamide Mechenism of Action |
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The
exact mechanism of action is not known for zonisamide.
According to Leppik, while zonisamide may be a carbonic
anhydrase inhibitor like acetazolamide, this is not one
of the primary mechanisms of action, which might be
blocking repetitive firing of voltage-gated sodium
channels and reduction of T-type Calcium channel
currents, or by binding allosterically to GABA receptors
like the benzodiazepines and muscimol, or increasing the
levels of the glutamate transport protein in the brain
while decreasing the amount of GABA transport protein,
in other words, inhibiting the uptake of the inhibitory
neurotransmitter GABA while enhancing the uptake of the
excitatory neurotransmitter glutamate. |
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Precautions Before Using Zonisamide |
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Before taking zonisamide,
-tell your
doctor and pharmacist if you are allergic to
zonisamide, celecoxib, diuretics ('water pills'), oral
medications for diabetes, sulfa drugs, or any other
medications.
-tell your
doctor if you have or have ever had liver or kidney
disease.
-tell your
doctor if you are pregnant, plan to become pregnant,
or are breast-feeding. If you become pregnant while
taking zonisamide, call your doctor. Zonisamide may
harm the fetus.
-if you are
having surgery, including dental surgery, tell the
doctor or dentist that you are taking zonisamide.
-you should know
that zonisamide may make you drowsy. Do not drive a
car or operate machinery until you know how this
medication affects you.
-remember that
alcohol can add to the drowsiness caused by this
medication.
-you should know
that you may be more likely to develop kidney stones
while taking zonisamide. You should drink 6-8 glasses
of water daily to help prevent kidney stones from
forming.
-you should know
that zonisamide can prevent you from sweating and make
it harder for your body to cool down when it gets very
hot. This happens most often in warm weather and to
children who take zonisamide. You should avoid
exposure to heat and notify your doctor if you have a
fever and/or are not sweating as usual. |
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Zonisamide side effects
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Zonisamide may cause side effects. Tell your doctor if
any of these symptoms are severe or do not go away:
-drowsiness
-loss of
appetite
-upset stomach
-vomiting
-weight loss
-changes in
taste
-dizziness
-constipation
-dry mouth
-headache
-confusion
-irritability
-difficulty
falling asleep or staying asleep
-difficulty with
memory
-pain, burning,
or tingling in the hands or feet
-difficulty
focusing eyes
-double vision
-sneezing
-runny nose
Some
side effects can be serious. The following symptoms are
uncommon, but if you experience any of them, call your
doctor immediately:
-rash
-worsening or
longer lasting seizures
-sudden back
pain
-stomach pain
-pain when
urinating
-bloody or dark
urine
-fever
-sore throat
-sores in mouth
-easy bruising
-depression
-unusual
thoughts
-difficulty
thinking of words or trouble speaking
-difficulty
thinking or concentrating
-lack of
coordination
-difficulty
walking
Zonisamide may cause other side effects. Call your
doctor if you have any unusual problems while taking
this medication. |
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What should you do if you miss a dose
of Zonisamide? |
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Take
the missed dose as soon as you remember it. However, if
it is almost time for the next dose, skip the missed
dose and continue your regular dosing schedule. Do not
take a double dose to make up for a missed one. |
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Overdose Zonisamide |
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In
case of overdose, call your local poison control center
at 1-800-222-1222. If the victim has collapsed or is not
breathing, call local emergency services at 911.
Symptoms of overdose may include:
-slow heartbeat
-difficulty
breathing
-dizziness
-fainting
-loss of
consciousness |
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Zonisamide Storage |
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Keep
this medication in the container it came in, tightly
closed, and out of reach of children. Store it at room
temperature and away from excess heat and moisture (not
in the bathroom). Throw away any medication that is
outdated or no longer needed. Talk to your pharmacist
about the proper disposal of your medication. |
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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