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Zolmitriptan
API |
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Haorui supplies high quality Zolmitriptan API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Zolmitriptan API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What
is Zolmitriptan? |
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Zolmitriptan is a synthetic indole derivative with the
empirical formula is C16H21N3O2. Zolmitriptan is a white
to almost white powder that is readily soluble in water. |
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What
is Zolmitriptan used for? |
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Zolmitriptan (zohl-mi-TRIP-tan) is used
to treat severe migraine headaches. Many people find
that their headaches go away completely after they take
zolmitriptan. Other people find that their headaches are
much less painful, and that they are able to go back to
their normal activities even though their headaches are
not completely gone. Zolmitriptan often relieves
symptoms that occur together with a migraine headache,
such as nausea, vomiting, sensitivity to light, and
sensitivity to sound.
Zolmitriptan is not an ordinary pain
reliever. It should not be used to relieve any kind of
pain other than migraine headaches.
Zolmitriptan may cause serious side
effects in some people, especially people who have heart
or blood vessel disease. Be sure that you discuss with
your doctor the risks of using this medicine as well as
the good that it can do. |
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Precautions Before Using Zolmitriptan |
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In deciding to use a medicine, the risks
of taking the medicine must be weighed against the good
it will do. This is a decision you and your doctor will
make. For zolmitriptan, the following should be
considered:
Allergies—Tell
your doctor if you have ever had any unusual or allergic
reaction to zolmitriptan. Also tell your health care
professional if you are allergic to any other
substances, such as foods, preservatives, or dyes.
Pregnancy—Zolmitriptan
has not been studied in pregnant women. However, in some
animal studies, zolmitriptan caused harmful effects to
the fetus. These unwanted effects usually occurred when
zolmitriptan was given in amounts that were large enough
to cause harmful effects in the mother.
Breast-feeding—Although
most medicines pass into breast milk in small amounts,
many of them may be used safely while breast-feeding.
Mothers who are taking this medicine and who wish to
breast-feed should discuss this with their doctor.
Children—There
is no specific information comparing use of zolmitriptan
in children or teenagers with use in other age groups.
Older adults—There
is no specific information comparing use of zolmitriptan
in patients older than 65 years of age with use in
younger adults.
Other medicines—Although
certain medicines should not be used together at all, in
other cases two different medicines may be used together
even if an interaction might occur. In these cases, your
doctor may want to change the dose, or other precautions
may be necessary. Tell your health care professional if
you are taking any other prescription or nonprescription
(over-the-counter [OTC]) medicine, especially other
prescription medicine for migraine headaches, or if you
smoke tobacco.
When you are taking zolmitriptan, it is
especially important that your health care professional
know if you are taking the following:
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Monoamine oxidase-A (MAO-A) inhibitor
activity (isocarboxazid [e.g., Marplan], phenelzine
[e.g., Nardil], procarbazine [e.g., Matulane],
selegiline [e.g., Eldepryl], tranylcypromine [e.g.,
Parnate])—Taking zolmitriptan while you are taking or
within 2 weeks of taking MAO inhibitors may cause
sudden high body temperature, extremely high blood
pressure, and severe convulsions; at least 14 days
should be allowed between stopping treatment with one
medicine and starting treatment with the other.
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Other medical problems—The
presence of other medical problems may affect the use of
zolmitriptan. Make sure you tell your doctor if you have
any other medical problems, especially:
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Angina (chest pain) or
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Fast or irregular heartbeat or
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Heart or blood vessel disease or
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High blood pressure or
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Kidney disease or |
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Liver disease or |
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Stroke (history of)—The chance of side
effects may be increased. Heart or blood vessel
disease and high blood pressure sometimes do not cause
any symptoms, so some people do not know that they
have these problems. Before deciding whether you
should use zolmitriptan, your doctor may need to do
some tests to make sure that you do not have any of
these conditions. |
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Phenylketonuria (PKU)—The oral
disintegrating tablets may contain aspartame, which
can make your condition worse |
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Zolmitriptan side effects |
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Along with its needed effects, a medicine
may cause some unwanted effects. Although not all of
these side effects may occur, if they do occur they may
need medical attention.
Stop using this medicine and check with
your doctor immediately if any of the following side
effects occur:
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Chest pain (severe); heaviness,
tightness, or pressure in chest and/or neck;
sensation of burning, warmth, heat, numbness,
tightness, or tingling |
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Abdominal pain (severe); changes in
facial skin color; cough or hoarseness; diarrhea;
fast or irregular heartbeat ; fever or chills; loss
of appetite; lower back or side pain; nausea;
painful or difficult urination ; puffiness or
swelling of the eyelids or around the eyes, face, or
lips; shortness of breath, troubled breathing,
tightness in chest, and/or wheezing; skin rash,
hives, and/or itching; weakness
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Other side effects may occur that usually
do not need medical attention. Some of the following
effects, such as nausea, vomiting, drowsiness,
dizziness, and general feeling of illness or tiredness,
often occur during or after a migraine, even when
zolmitriptan has not been used. However, check with your
doctor if any of the following side effects continue or
are bothersome:
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Dizziness; nausea; sleepiness;
unusual tiredness or muscle weakness
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Agitation; anxiety; depression;
discomfort in jaw, mouth, or throat; difficulty in
swallowing; dry mouth ; fainting; heartburn;
itching of the skin; large nonelevated blue or
purplish patches in the skin; muscle aches ;
pounding heartbeat; sudden large increase in
frequency and quantity of urine; sweating; swelling
of face, fingers, feet and/or lower legs |
Other side effects not listed above may
also occur in some patients. If you notice any other
effects, check with your doctor. |
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Overdose Zolmitriptan |
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In case of overdose, call your local
poison control center at 1-800-222-1222. If the victim
has collapsed or is not breathing, call local emergency
services at 911.
Symptoms of overdose may include:
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sleepy, quiet state.
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Zolmitriptan Storage |
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Keep out of the reach of children since
overdose is especially dangerous in children.
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Store away from heat and direct light.
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Do not store tablets in the bathroom,
near the kitchen sink, or in other damp places. Heat
or moisture may cause the medicine to break down.
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Do not keep outdated medicine or
medicine no longer needed. Be sure that any discarded
medicine is out of the reach of children.
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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