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Topotecan HCl
API |
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Haorui supplies high quality Topotecan HCl API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Topotecan HCl API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Topotecan HCl?
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Topotecan
is a cancer (antineoplastic) medication. Topotecan
interferes with the growth of cancer cells and slows
their growth and spread in the body. |
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Topotecan is used in the treatment of
cancers of the lung, ovary, and blood. |
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Topotecan may also be used for purposes other than those
listed in this medication guide. |
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What should I do before use Topotecan HCl ?
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Allergies?
Tell
your doctor if you have ever had any unusual or allergic
reaction to topotecan. Also tell your health care
professional if you are allergic to any other
substances. |
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Pregnancy? Tell
your doctor if you are pregnant. Studies in rats and
rabbits have shown that topotecan causes birth defects
and deaths of the fetus, as well as problems in the
mother. |
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Be sure that you have discussed this with
your doctor before starting treatment with this
medicine. It is best to use birth control while you are
receiving topotecan. Also, tell your doctor right away
if you think you have become pregnant during treatment. |
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Breast-feeding?
It
is not known whether topotecan passes into breast milk.
However, because this medicine may cause serious side
effects, breast-feeding is generally not recommended
while you are receiving it. |
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Children? Topotecan
has been studied in a limited number of children. One
study showed that seriously low blood counts may be more
likely to occur in children than in adults. |
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Older adults? This
medicine has been tested in elderly patients and has not
been shown to cause different side effects or problems
in older people than it does in younger adults. |
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Precautions of Topotecan HCl |
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It is very important that your doctor
check your progress at regular visits to make sure that
this medicine is working properly and to check for
unwanted effects. Some of the side effects of this
medicine do not have any symptoms and must be found with
a blood test. |
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While you are being treated with
topotecan, and after you stop treatment with it, do
not have any immunizations (vaccinations) without your
doctor's approval. Topotecan may lower your body's
resistance, and there is a chance you might get the
infection the immunization is meant to prevent. In
addition, other persons living in your household should
not take oral polio vaccine, since there is a chance
they could pass the polio virus on to you. Also, avoid
persons who have taken oral polio vaccine within the
past several months. Do not get close to them and do not
stay in the same room with them for very long. If you
cannot take these precautions, you should consider
wearing a protective face mask that covers the nose and
mouth. |
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Topotecan can temporarily lower the
number of white blood cells in your blood, increasing
the chance of getting an infection. It can also lower
the number of platelets, which are needed for proper
blood clotting. If this occurs, there are certain
precautions you can take, especially when your blood
count is low, to reduce the risk of infection or
bleeding: |
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-If you can, avoid people with
infections. Check with your doctor immediately if you
think you are getting an infection or if you get a
fever or chills, cough or hoarseness, lower back or
side pain, or painful or difficult urination.
-Check
with your doctor immediately
if you notice any unusual bleeding or bruising; black,
tarry stools; blood in urine or stools; or pinpoint
red spots on your skin.
-Be careful when using a regular
toothbrush, dental floss, or toothpick. Your medical
doctor, dentist, or nurse may recommend other ways to
clean your teeth and gums. Also, check with your
medical doctor before having any dental work done.
-Do not touch your eyes or the inside of
your nose unless you have just washed your hands and
have not touched anything else in the meantime.
-Be careful not to cut yourself when you
are using sharp objects such as a safety razor or
fingernail or toenail cutters.
-Avoid contact sports or other
situations where bruising or injury could occur. |
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Topotecan
HCl side effects
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Each person's reaction to chemotherapy is
unique. Some people have very few side effects, while
others may experience more. The side effects described
in this section will not affect everyone who is given
topotecan, and may be different if you are having more
than one chemotherapy drug.
We have outlined the most common side
effects and those that are less common, so that you can
be aware of them if they occur. However, we have not
included those which are very rare and therefore
extremely unlikely to affect you. If you notice any
effects which you think may be due to the drug, but
which are not listed here, please discuss them with your
doctor or chemotherapy nurse.
Temporary reduction in the production of
blood cells by the bone marrow.
This can result in anemia leading to tiredness; an
increased risk of bruising or bleeding and an increased
risk of infection. The number of cells in your blood may
begin to reduce from about seven days after the
treatment has been given and usually reaches its lowest
point at 10-14 days after the chemotherapy. Your blood
cells will then increase steadily and will usually
return to normal within 21-28 days. Your blood will be
checked regularly to see how well your bone marrow is
working.
If your temperature goes above 38C
(100.5F); you develop any unexplained bruising or
bleeding; or you suddenly feel unwell, even with a
normal temperature, contact your doctor or the hospital
straight away.
Feeling sick (nausea) or being sick
This is usually mild and there are now very effective
anti-sickness drugs to prevent or greatly reduce nausea
and vomiting. If you do feel sick it may begin a few
hours after the treatment is given and can last for up
to a day. If the sickness is not controlled, or
continues, tell your doctor, who can prescribe other
anti-sickness drugs, which may be more effective.
Loss of appetite
is also usually mild and may last a day or so.
Cancer BACUP's information on diet and the cancer patient
has tips on boosting your appetite, coping with eating
difficulties and maintaining weight. The dietitian at
the hospital can be very helpful.
Hair loss
usually starts 3-4 weeks after the first dose of
topotecan. Hair may be lost completely or may just thin.
You may also have thinning and loss of eyelashes,
eyebrows and other body hair. This is temporary and your
hair will regrow once the treatment is finished.
Tiredness and a general feeling of
weakness
It is important to allow yourself plenty of time to
rest. |
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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