Tacrolimus API (DMF ready)

Haorui supplies high quality Tacrolimus API produced by our GMP facility that has been successfully inspected by the FDA. We offer competitive prices and support our products with reliable technical and regulatory services.  Tacrolimus API is available from R&D to commercial quantities. Please contact us for more details.

  The following information is provided for general information purposes ONLY.

Tacrolimus ointment is mainly indicated for the treatment of moderate to severe atopic dermatitis in adults and children who are: responding poorly to conventional therapy (emollients, topical and oral steroids, antibiotics, phototherapy) and/or suffering side effects from conventional therapy.

Children should only be treated with tacrolimus ointment 0.03%. A stronger ointment (0.1%) is also available for adults. Studies have shown that treatment with topical tacrolimus show benefits after about one week and maximum improvement at about 3 months.  

Tacrolimus is used to prevent rejection of liver transplants. Sometimes it is used to prevent rejection of other types of transplants.  

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.  

1. tell your doctor and pharmacist if you are allergic to tacrolimus or any other drugs.  

2. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking tacrolimus, call your doctor.  

3. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking tacrolimus.  

Tacrolimus ointment is a prescription medicine and should be used only as directed by your doctor. Initial treatment will be for a short period to assess the response. If it is effective it may be continued long-term (6-12 months) if required. A thin layer of ointment should be rubbed in gently and completely onto the affected area(s) twice daily.  

Most patients tolerate tacrolimus ointment well. The most common side effect that can be experienced around the site of application is a feeling of warmth or a sensation of burning. This is usually mild to moderate in severity and goes away within a few days after starting treatment. However, if this reaction persists for more than one week you should see your doctor. Other less common side effects include headache, cough, fever, flu-like symptoms, muscle aches, infection of the hair follicle (folliculitis) and acne. Unlike topical corticosteroids, topical tacrolimus has not been shown to cause skin thinning, hence it is suitable for application to areas of skin that are thin such as the face, neck and flexures.There are concerns however that topical tacrolimus may aggravate herpes simplex and other viral infections. Long term use of oral tacrolimus, like other immune suppressive agents, is known to increase the risk of skin cancer.  

Tacrolimus comes as a capsule to take by mouth and in an injectable form. It usually is taken twice a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tacrolimus exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.  Continue to take tacrolimus even if you feel well. Do not stop taking tacrolimus without talking to your doctor. You will probably take tacrolimus for a long time.  

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.  

Although side effects from tacrolimus are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away: diarrhea, upset stomach, vomiting, stomach pain, loss of appetite, insomnia  

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.  

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to tacrolimus and do blood tests to see how your liver and kidneys are working.  

Tacrolimus can raise your blood pressure. Talk to your doctor about checking your blood pressure regularly.  

Before receiving any vaccinations, tell your doctor that you are taking tacrolimus.