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Sunitinib malate
API |
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Haorui supplies high quality Sunitinib malate API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Sunitinib malate API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Sunitinib malate? |
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Sunitinib is used to treat gastrointestinal
stromal tumors (GIST; a type of tumor that grows in the
stomach, intestine (bowel), or esophagus (tube that connects
the throat with the stomach) in people with tumors that were
not treated successfully with imatinib (Gleevec) or people
who cannot take imatinib. Sunitinib is also used to treat
advanced renal cell carcinoma (RCC, a type of cancer that
begins in the cells of the kidneys). Sunitinib is in a class
of medications called multikinase inhibitors. It works by
blocking the action of the abnormal protein that signals
cancer cells to multiply. This helps stop or slow the spread
of cancer cells and may help shrink tumors. |
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How should
Sunitinib malate be used?
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Sunitinib comes as a capsule to take by
mouth with or without food. It is usually taken once a day
for 4 weeks (28 days) followed by a 2-week break before
beginning the next dosing cycle. Take sunitinib at around
the same time every day. Follow the directions on your
prescription label carefully, and ask your doctor or
pharmacist to explain any part you do not understand. Take
sunitinib exactly as directed. Do not take more or less of
it or take it more often than prescribed by your doctor.
Swallow the capsules whole; do not
split, chew, or crush them.Do not open the capsules.
You may need to take one or more
capsules at a time depending on your dose of sunitinib.
Your doctor may gradually increase or
decrease your dose of sunitinib during your treatment. This
depends on how well the medication works for you and the
side effects you experience. Talk to your doctor about how
you are feeling during your treatment. Continue to take
sunitinib even if you feel well. Do not stop taking
sunitinib without talking to your doctor.
Ask your pharmacist or doctor for a copy
of the manufacturer's information for the patient. |
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Other uses for
Sunitinib malate
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Sunitinib malate may be
prescribed for other uses; ask your doctor or pharmacist for
more information. |
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What special precautions should I follow?
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Before taking sunitinib,
 | tell your doctor
and pharmacist if you are allergic to sunitinib, mannitol,
or any other medications. |
| tell your doctor
and pharmacist what prescription and nonprescription
medications, vitamins, and nutritional supplements you are
taking or plan to take. Be sure to mention any of the
following: certain antibiotics such as clarithromycin (Biaxin,
in Prevpac), erythromycin (E.E.S., E-Mycin, Erythrocin),
moxifloxacin (Avelox), rifampin (Rifadin, Rimactane),
rifabutin (Mycobutin), rifapentine (Priftin), sparfloxacin
(Zagam) (not available in the US), telithromycin (Ketek),
and troleandomycin (TAO) (not available in the US);
anticoagulants ('blood thinners') such as warfarin (Coumadin);
antifungals such as itraconazole (Sporanox), ketoconazole
(Nizoral), and voriconazole (Vfend); certain calcium
channel blockers such as diltiazem (Cardizem, Dilacor,
Tiazac, others) and verapamil (Calan, Isoptin, Verelan);
cimetidine (Tagamet); cisapride (Propulsid); dexamethasone
(Mymethasone); certain medications for depression such as
fluvoxamine and nefazodone; certain medications for human
immunodeficiency virus (HIV) or acquired immunodeficiency
syndrome (AIDS) including atazanavir (Reyataz), indinavir
(Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in
Kaletra), and saquinavir (Invirase); medications for
irregular heartbeat including amiodarone (Cordarone),
disopyramide (Norpace), dofetilide (Tikosyn)procainamide (Procanbid,
Pronestyl), quinidine (Quinidex), and sotalol (Betapace,
Betapace AF); certain medications for seizures such as
carbamazepine (Equetro, Carbatrol, Tegretol),
phenobarbital, and phenytoin (Dilantin, Phenytek);
pimozide (Orap); and thioridazine (Mellaril). Other
medications may also interact with sunitinib, so be sure
to tell your doctor about all the medications you are
taking, even those that do not appear on this list. Your
doctor may need to change the doses of your medications or
monitor you carefully for side effects. |
| tell your doctor
and pharmacist what herbal products you are taking,
especially St. John's wort. Your doctor will probably tell
you not to take St. John's wort while taking sunitinib.
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| tell your doctor
if you have or have ever had a bleeding problem;angina
(chest pain); arrhythmias (slow, fast, or irregular heart
beat);a heart attack; heart bypass surgery; heart failure;
high blood pressure; pulmonary embolism (PE; blood clot in
the lungs); seizures; a stroke or transient ischemic
attack (TIA, mini-stroke); or heart, kidney, liver, or
thyroid disease. |
| tell your doctor
if you are pregnant, could be pregnant, or plan to become
pregnant. You should not become pregnant while you are
taking sunitinib. Talk to your doctor about birth control
methods that you can use during your treatment. If you
become pregnant while taking sunitinib, call your doctor
immediately Sunitinib may harm the fetus. |
| tell your doctor
if you are breast-feeding. You should not breast-feed
while you are taking sunitinib. |
| if you are
having surgery, including dental surgery, tell the doctor
or dentist that you are taking sunitinib. |
| you should know
that sunitinib may cause your skin to turn yellow and your
hair to lighten and lose color. This is probably caused by
the yellow color of the medication and is not harmful or
painful. Your natural skin and hair color will likely
return after you stop taking sunitinib. |
| you should know
that sunitinib may cause high blood pressure. Your blood
pressure should be checked regularly while you are taking
sunitinib. |
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What side effects can
Sunitinib malate cause?
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Sunitinib may cause side effects. Tell
your doctor if any of these symptoms are severe or do not go
away:
| extreme
tiredness |
| weakness
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| nausea
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| vomiting
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| diarrhea
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| constipation
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| heartburn
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| gas |
| white patches or
sores on the lips or in the mouth and throat |
| pain,
irritation, or burning sensation of the lips, tongue,
mouth or throat |
| dry mouth
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| change in the
way things taste |
| loss of appetite
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| weight loss
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| hair loss
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| thin, brittle
fingernails or hair |
| slow speech
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| depression
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| dryness,
thickness, cracking, or blistering of skin on the palms of
the hands and the soles of the feet |
| rash
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| muscle or limb
pain |
| pain, burning,
numbness, or tingling in the hands or feet |
| unusual
discomfort in cold temperatures |
Some side effects can be serious. If you
experience any of these symptoms,call your doctor
immediately:
| unusual bruising
or bleeding |
| black and tarry
stools |
| red blood in
stools |
| bloody vomit
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| vomiting
material that looks like coffee grounds |
| stomach pain or
swelling |
| fever
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| chills
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| swelling,
tenderness, warmth, or redness of a leg |
| swelling of the
feet or ankles |
| rapid,
irregular, or pounding heartbeat |
| chest pain
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| shortness of
breath |
| weight gain
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| difficulty
falling asleep or staying asleep |
| coughing up pink
or bloody mucus |
| increased
urination, especially at night |
| sudden severe
back, stomach, or leg pain |
Sunitinib may cause other side effects.
Call your doctor if you have any unusual problems while
taking this medication. |
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What storage conditions are needed for
Sunitinib malate?
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Keep
Sunitinib malate in the
container it came in, tightly closed, and out of reach of
children. Store it at room temperature and away from excess
heat and moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to
your pharmacist about the proper disposal of your
medication. |
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What other information should I know? |
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Keep all appointments with your doctor
and the laboratory. Your doctor will order certain lab tests
to check your body's response to sunitinib.
Do not let anyone else take your
medication. Ask your pharmacist any questions you have about
refilling your prescription. |
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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