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Mifepristone
API |
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Haorui supplies high quality Mifepristone API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Mifepristone API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What
is Mifepristone? |
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Mifepristone is used alone or in combination with
misoprostol to end an early pregnancy. Early pregnancy
means it has been 49 days or less since your last
menstrual period began. Mifepristone is in a class of
medications called antiprogestational steroids.
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How Mifepristone should be used? |
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Mifepristone comes as a tablet to take by mouth. It
should be taken only in a clinic, medical office, or
hospital under the supervision of a qualified doctor.
You will take three tablets of mifepristone at one time
on the first day. Two days later you must go back to
your doctor. If your doctor is not certain that your
pregnancy has ended, you will take two tablets of
another medication called misoprostol. You may have
vaginal bleeding for 9 to 30 days or longer. Fourteen
days after taking mifepristone, you must go back to your
doctor for an exam or ultrasound to make sure that the
pregnancy has ended. Take mifepristone exactly as
directed. |
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Mifepristone’s Other Use |
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Mifepristone is also sometimes used to end pregnancies
when more than 49 days have passed since the woman's
last menstrual period; as an emergency contraceptive
after unprotected sexual intercourse ('morning-after
pill'); to treat tumors of the brain, endometriosis
(growth of uterus tissue outside the uterus), or
fibroids (noncancerous tumors in the uterus); or to
induce labor (to help start the birth process in a
pregnant woman). Talk to your doctor about the possible
risks of using this drug for your condition. |
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How does Mifepristone work?
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Mifepristone
works by blocking the activity of progesterone, a
substance your body makes to help continue pregnancy. |
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Mifepristone Side Effects |
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Mifepristone may cause side effects. Tell your doctor if
any of these symptoms are severe or do not go away:
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vaginal bleeding or spotting
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cramps |
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pelvic pain |
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vaginal burning, itching, or discharge
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headache |
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tiredness |
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difficulty falling asleep or staying
asleep |
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anxiety |
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back or leg pain |
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What precautions should you follow
before taking Mifepristone? |
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Allergies—Tell your doctor if
you have ever had any unusual or allergic reaction to
mifepristone, misoprostol or any other prostaglandins.
Pregnancy—Mifepristone is used
to terminate an early pregnancy. Fetal deformities may
result if a pregnancy is allowed to continue following a
failed attempt at medical termination.
Breast-feeding—It is unknown
whether mifepristone is distributed in the breast milk.
It may be necessary for you to stop breast-feeding
during treatment. Be sure you have discussed the risks
and benefits of this treatment with your doctor.
Other medicines—Although
certain medicines should not be used together at all, in
other cases two different medicines may be used together
even if an interaction might occur. In these cases, your
doctor may want to change the dose, or other precautions
may be necessary. When you are taking mifepristone, it
is especially important that your doctor and pharmacist
know if you are taking any of the following:
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Carbamazepine
(e.g., Tegretol) or |
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Dexamethasone
(e.g., Decadron) or |
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Phenobarbital
(e.g., Luminal) or |
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Phenytoin
(e.g., Dilantin) or |
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Rifampin (e.g.,
Rifadin) or |
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St. John's Wort
— May decrease the concentration of mifepristone in
the blood |
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Erythromycin
(e.g., E-Mycin) or |
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Grapefruit
juice or |
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Itraconazole
(e.g., Sporanox) or |
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Ketoconazole
(e.g., Nizoral) — May increase the concentration of
mifepristone in the blood |
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Anticoagulants,
such as warfarin (e.g., Coumadin) — May increase the
risk of bleeding |
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Corticosteroids
(cortisone-like medicine)—Mifepristone may not work as
well |
Other medical problems—The
presence of other medical problems may affect the use of
mifepristone. Make sure you tell your doctor if you have
any other medical problems, especially:
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Adrenal
failure—Mifepristone may not work appropriately
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Bleeding
problems—May cause excessive vaginal bleeding
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Diabetes or
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Heart disease
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High blood
pressure or |
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Kidney disease
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Liver disease
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Lung disease
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Women older
than 35 years of age who smoke cigarettes (10 or more
a day)—You should use caution if you have any of these
chronic conditions and let your doctor know before
beginning treatment with this medicine. |
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Ectopic
pregnancy or |
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Lower abdominal
mass—Mifepristone will not terminate an ectopic
pregnancy |
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An intrauterine
device (IUD) that is still in the uterus—Must be
removed before mifepristone therapy is started
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Porphyria,
inherited |
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Anemia, severe
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Poor blood
circulation or |
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Inability of
blood to clot properly—Mifepristone causes heavy
bleeding in a small portion of users, this may be
intensified in patients with bleeding disorders
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What should you do, if you overdose
Mifepristone? |
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In
case of overdose, call your local poison control center
at 1-800-222-1222. If the victim has collapsed or is not
breathing, call local emergency services at 911.
Symptoms of overdose may include:
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dizziness |
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fainting |
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blurred vision |
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upset stomach |
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tiredness |
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weakness |
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shortness of breath
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fast heart beat |
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Special dietary instructions while
taking Mifepristone |
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Do
not take mifepristone with grapefruit juice. Talk to
your doctor about drinking grapefruit juice after taking
Mifepristion. |
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Disclaimer:
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Information on this page is provided
for general information purposes. You should not make a
clinical treatment decision based on information
contained in this page without consulting other
references including the package insert of the drug,
textbooks and where relevant, expert opinion. We cannot
be held responsible for any errors you make in
administering drugs mentioned on this page, nor for use
of any erroneous information contained on this page.
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