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Methazolamide
API |
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Haorui supplies high quality Methazolamide API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Methazolamide API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
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What is Methazolamide? |
Methazolamide is used for treating certain
types of glaucoma. It may also be used for other conditions
as determined by your doctor.
Methazolamide is a carbonic anhydrase inhibitor. It reduces
fluid pressure in the eyeball by decreasing fluid formation
in the eyeball. |
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Do NOT use Methazolamide if: |
you are allergic to any ingredient in
Methazolamide
you have adrenal gland problems, low blood levels of
potassium or sodium, kidney problems, liver problems (eg,
cirrhosis), or high blood levels of chloride or other
electrolyte problems
Contact your doctor or health care provider right away if
any of these apply to you. |
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Before using Methazolamide : |
Some medical conditions may interact with Methazolamide .
Tell your doctor or pharmacist if you have any medical
conditions, especially if any of the following apply to you:
 | if you are
pregnant, planning to become pregnant, or are
breast-feeding |
| if you are
taking any prescription or nonprescription medicine,
herbal preparation, or dietary supplement |
| if you have
allergies to medicines, foods, or other substances
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| if you have
kidney stones, a lung disease, glaucoma (eg, chronic
non-congestive angle-closure glaucoma), diabetes, or
difficulty breathing |
| if you have had
a severe allergic reaction (eg, a severe rash, hives,
breathing difficulties, or dizziness) to any other
sulfonamide medicine such as acetazolamide, celecoxib,
certain diuretics (eg, hydrochlorothiazide), glyburide,
probenecid, sulfamethoxazole, valdecoxib, or zonisamide
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Some MEDICINES MAY INTERACT with Methazolamide . Tell
your health care provider if you are taking any of the
following medicines:
| Salicylates (eg,
aspirin) because the risk of toxic side effects of
Methazolamide may be increased |
| Other carbonic
anhydrase inhibitors (eg, acetazolamide), cyclosporine,
quinidine, phenytoin, amphetamine, or sodium bicarbonate
because the actions and side effects of these medicines
may be increased |
| Primidone,
lithium, or methenamine because the effectiveness of these
medicines may be decreased |
This may not be a complete list of all interactions that
may occur. Ask your health care provider if Methazolamide
may interact with other medicines that you take. Check with
your health care provider before you start, stop, or change
the dose of any medicine. |
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How to use Methazolamide : |
| Use
Methazolamide as directed by your doctor. Check the label
on the medicine for exact dosing instructions.
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| Methazolamide
may be taken with or without food. If stomach upset
occurs, take with food to reduce stomach irritation.
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| Drink plenty of
water or fluids while taking Methazolamide . |
| When you first
start taking Methazolamide , it may cause an increase in
urine or in frequency of urination. |
| To prevent this
from affecting sleep, try not to take Methazolamide later
than 6 pm. |
| If a dose is
missed, take it as soon as possible. If it is almost time
for your next dose, skip the missed dose and go back to
your regular dosing schedule. Do not take 2 doses at once.
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| Ask your health
care provider any questions you may have about how to use
Methazolamide . |
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Important safety information: |
| Methazolamide
may cause drowsiness or temporary vision changes. Do not
drive, operate machinery, or do anything else that could
be dangerous until you know how you react to Methazolamide
. Using Methazolamide alone, with certain other medicines,
or with alcohol may lessen your ability to drive or
perform other potentially dangerous tasks. |
| Methazolamide
may cause increased sensitivity to the sun. Avoid exposure
to the sun, sunlamps, or tanning booths until you know how
you react to Methazolamide . Use a sunscreen or protective
clothing if you must be outside for a prolonged period.
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| Before you have
any medical or dental treatments, emergency care, or
surgery, tell the doctor or dentist that you are using
Methazolamide . |
| Methazolamide
may interfere with certain lab tests. Make sure your
doctor and laboratory personnel know you are taking
Methazolamide . |
| Diabetes
patients - Methazolamide may affect your blood sugar.
Check blood sugar levels closely and ask your doctor
before adjusting the dose of your diabetes medicine.
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| LAB TESTS,
including blood electrolyte levels, complete blood cell
count, or platelet levels, may be performed to monitor
your progress or to check for side effects. Be sure to
keep all doctor and lab appointments. |
| Use
Methazolamide with caution in the ELDERLY because they may
be more sensitive to its effects. |
| Use
Methazolamide with extreme caution in CHILDREN. Safety and
effectiveness have not been confirmed. |
| PREGNANCY and
BREAST-FEEDING: If you become pregnant, discuss with your
doctor the benefits and risks of using Methazolamide
during pregnancy. It is unknown if Methazolamide is
excreted in breast milk. Do not breast-feed while taking
Methazolamide . |
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Possible side effects of Methazolamide : |
All medicines may cause side effects, but many people have
no, or minor, side effects. Check with your doctor if any of
these most COMMON side effects persist or become bothersome:
Blurred vision; changes in taste; constipation; diarrhea;
drowsiness; frequent urination; loss of appetite; nausea;
vomiting.
Seek medical attention right away if any of these SEVERE
side effects occur:
Severe allergic reactions (rash; hives; difficulty
breathing; tightness in the chest; swelling of the mouth,
face, lips, or tongue); blood in urine; changes in hearing;
convulsions; dark, bloody stools; dark urine; fast
breathing; fever; lack of energy; lower back pain; red,
swollen, or blistered skin; ringing in the ears; sore
throat; tingling of the arms or legs; unusual bleeding or
bruising; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may
occur. If you have questions or need medical advice about
side effects, contact your doctor or health care provider.
You may report side effects to the FDA at 1-800-FDA-1088
(1-800-332-1088) or at http://www.fda.gov/medwatch. |
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If OVERDOSE is suspected: |
| Contact 1-800-222-1222 (the American Association of Poison
Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm),
or emergency room immediately. Symptoms may include abnormal
skin sensations (eg, tingling, tickling, itching, burning);
buzzing, ringing, or whistling in the ears; drowsiness; loss
of appetite; loss of coordination; nausea; tremors; unsteady
movements; vomiting. |
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Proper storage of Methazolamide :
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| Store Methazolamide at room temperature, between 59 and 86
degrees F (15 and 30 degrees C), in a tightly closed
container. Store away from heat, moisture, and light. Do not
store in the bathroom. Keep Methazolamide out of the reach
of children and away from pets. |
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General information: |
If you have any questions about Methazolamide , please talk
with your doctor, pharmacist, or other health care provider.
Methazolamide is to be used only by the patient for whom it
is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse,
check with your doctor.
This information is summary only. It does not contain all
information about Methazolamide . If you have questions
about the medicine you are taking or would like more
information, check with your doctor, pharmacist, or other
health care provider. |
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Disclaimer:
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Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
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What is Galanthamine?
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Galanthamine
comes from the bulbs of a spring flower called
common snowdrop. The herb is available as a chemical
synthetic in coated tablets and ampules. Some
research shows assistance with Alzheimer's disease
with this herb; however, more research is underway
at this time.
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A
cholinesterase inhibitor derived from the plant, Galanthus. It has been used to reverse the muscular
effects of Gallamine Triethiodide and Tubocurarine
and has been studied as a treatment for Alzheimer
diseas and other central
nervous system disorders.
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How does Galanthamine work?
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Many people use
Galanthamine for the following:
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Alzheimer's disease
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Myasthenia gravis
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Post-polio Paralysis
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To reverse neuromuscular blockade (in which drugs
are given to stop unwanted muscle movement)
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The history of Galanthamine
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Derived
from bulbs of the common snowdrop and several
Amaryllidaceae plants, (-)-galanthamine (GAL) has
long been used in anaesthetics to reverse
neuromuscular paralysis induced by turbocurarine-like
muscle relaxants and more recently, has been shown
to attenuate drug- and lesion-induced cognitive
deficits in animal models of learning and memory.
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What is Galanthamine used
for?
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GAL directly inhibits
acetylcholinesterase activity, while demonstrating
much weaker activity on butyrylcholinesterase (BuChE).
GAL also stimulates pre- and postsynaptic nicotinic
receptors, although the clinical significance of
this finding is yet unclear. Numerous variants and
analogues of GAL have also been developed, with
varying potency in inhibiting AChE activity. GAL is
readily absorbed after oral administration, with a
t(max) of 52 min and a plasma elimination t(1/2) of
5.7 h. The efficacy of GAL administered to
Alzheimer's disease (AD) patients has been well
demonstrated by large-scale clinical trials.
Typical of AChEIs, the most common adverse events
associated with GAL are nausea and vomiting.
In conclusion, evidence to date suggests
galanthamine to be similar to other AChEIs in
improving cognitive function in AD patients.
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Disclaimer:
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Information on
this page is provided for general information
purposes. You should not make a clinical treatment
decision based on information contained in this page
without consulting other references including the
package insert of the drug, textbooks and where
relevant, expert opinion. We cannot be held
responsible for any errors you make in administering
drugs mentioned on this page, nor for use of any
erroneous information contained on this page.
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