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Imatinib mesylate
API |
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Haorui supplies high quality Imatinib mesylate API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Imatinib mesylate API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Imatinib mesylate? |
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Imatinib is used to treat certain types of
leukemia (cancer that begins in the white blood cells) and
other cancers of the blood cells. Imatinib is also used to
treat gastrointestinal stromal tumors (GIST; a type of tumor
that grows in the walls of the digestive passages and may
spread to other parts of the body). Imatinib is also used to
treat dermatofibrosarcoma protuberans (a tumor that forms
under the top layer of skin) when the tumor cannot be
removed surgically, has spread to other parts of the body,
or has come back after surgery. Imatinib is in a class of
medications called protein-tyrosine kinase inhibitors. It
works by blocking the action of the abnormal protein that
signals cancer cells to multiply.This helps stop the spread
of cancer cells. |
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How should
Imatinib mesylate be used? |
Imatinib comes as a tablet to take by mouth.
It is usually taken with a meal and a large glass of water
once or twice a day. Take imatinib at around the same time(s)
every day. Follow the directions on your prescription label
carefully, and ask your doctor or pharmacist to explain any
part you do not understand. Take imatinib exactly as
directed. Do not take more or less of it or take it more
often than prescribed by your doctor.
If you are unable to swallow imatinib tablets, you may place
all of the tablets that you need for one dose into a glass
of water or apple juice. Use 50 mL (a little less than 2
ounces) of liquid for each 100 mg tablet and 100 mL (a
little less than 4 ounces) of liquid for each 400 mg tablet.
Stir with a spoon until the tablets crumble completely and
drink the mixture immediately.
If your doctor has told you to take 800 mg of imatinib, you
should take two of the 400 mg tablets. Do not take 8 of the
100 mg tablets. The tablet coating contains iron, and you
will receive too much iron if you take 8 of the 100 mg
tablets.
Your doctor may increase or decrease your dose of imatinib
during your treatment. This depends on how well the
medication works for you and on the side effects you
experience. Talk to your doctor about how you are feeling
during your treatment. Continue to take imatinib even if you
feel well. Do not stop taking imatinib without talking to
your doctor. |
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Other uses for
Imatinib mesylate |
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Imatinib mesylate may be
prescribed for other uses; ask your doctor or pharmacist for
more information. |
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What special precautions should I follow? |
Before taking imatinib,
 | tell your doctor and pharmacist if you are allergic to
imatinib or any other medications. |
| tell your doctor and pharmacist what prescription and
nonprescription medications, vitamins, and nutritional
supplements you are taking or plan to take. Be sure to
mention any of the following: acetaminophen (Tylenol);
certain antibiotics including erythromycin (E.E.S., E-Mycin,
Erythrocin), clarithromycin (Biaxin), and rifampin (Rifadin,
in Rifamate); anticoagulants ('blood thinners') such as
warfarin (Coumadin); antifungals such as ketoconazole (Nizoral)
and itraconazole (Sporanox); calcium channel blockers such
as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem,
Tiazac), felodipine (Plendil), isradipine (Dynacirc),
nicardipine (Cardene), nifedipine (Adalat, Procardia,
others), nimodipine (Nimotop), nisoldipine (Sular), or
verapamil (Calan, Covera, Isoptin, Verelan);
cholesterol-lowering medications (statins) such as
atorvastatin (Lipitor), lovastatin (Mevacor), and
simvastatin (Zocor); cyclosporine (Neoral, Sandimmune);
dexamethasone; hormonal contraceptives (birth control
pills, patches, rings, injections or implants); pimozide (Orap);
medications for anxiety; medications for seizures such as
carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin);
sedatives; sleeping pills; and tranquilizers. Other
medications may also interact with imatinib, so be sure to
tell your doctor about all the medications you are taking,
even those that do not appear on this list. Your doctor
may need to change the doses of your medications or
monitor you carefully for side effects. |
| tell your doctor what herbal products you are taking,
especially St. John's wort. |
| tell your doctor if you have or have ever had high
blood pressure a heart attack; an irregular heartbeat;
diabetes; or heart, lung, thyroid, or liver disease. Also
tell your doctor if you smoke, if you use street drugs,
and if you drink or have ever drunk large amounts of
alcohol. |
| tell your doctor if you are pregnant or plan to become
pregnant. You should not become pregnant while you are
taking imatinib. Talk to your doctor about birth control
methods that you can use during your treatment. If you
become pregnant while taking imatinib, call your doctor.
Imatinib may harm the fetus. |
| tell your doctor if you are breast-feeding. You should
not breast-feed while you are taking imatinib.
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| talk to your doctor about what you should do if you
develop diarrhea during your treatment. Do not take any
medications to treat diarrhea without talking to your
doctor.
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What side effects can
Imatinib mesylate cause?
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Imatinib may cause side effects. Tell your doctor if any of
these symptoms are severe or do not go away:
| diarrhea
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| constipation
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| gas
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| nausea
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| vomiting
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| loss of appetite
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| indigestion
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| joint pain
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| muscle cramps
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| depression
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| anxiety
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| night sweats
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| teary eyes
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Some side effects can be serious. If you experience any
of these symptoms call your doctor immediately:
| puffiness under the eyes
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| swelling of the hands, feet, ankles, or lower legs
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| weight gain
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| shortness of breath
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| fast, irregular, or pounding heartbeat
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| difficulty falling asleep or staying asleep
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| fainting
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| coughing up pink or bloody mucus
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| increased urination, especially at night
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| chest pain
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| fever
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| rash or blisters
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| yellowing of the skin or eyes
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| blood in the stool
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| unusual bruising or bleeding
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| sore throat, fever, chills, and other signs of
infection |
| excessive tiredness or weakness
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| headache
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| dizziness
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| Imatinib may cause other side effects. Call your doctor if
you have any unusual problems while taking this medication. |
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What storage conditions are needed for
Imatinib mesylate? |
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Keep
Imatinib mesylate in the
container it came in, tightly closed, and out of reach of
children. Store it at room temperature and away from excess
heat and moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to
your pharmacist about the proper disposal of your
medication. |
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Disclaimer:
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Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
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