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Entecavir
API |
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Haorui supplies high quality Entecavir API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services. Entecavir API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Entecavir? |
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Entecavir is
indicated for the treatment of chronic hepatitis B virus (HBV)
infection in adults with evidence of active viral
replication and either evidence of persistent elevations in
serum aminotransferases (ALT or AST) or histologically
active disease. |
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What is Entecavir used for? |
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Entecavir is used to treat
chronic (long-term) hepatitis B infection (swelling of the
liver caused by a virus) in people who show signs of liver
damage. Entecavir is in a class of medications called
nuceloside analogs. It works by decreasing the amount of
hepatitis B virus (HBV) in the body. Entecavir does not cure
hepatitis B and may not prevent complications of chronic
hepatitis B such as cirrhosis of the liver or liver cancer.
Entecavir does not prevent the spread of hepatitis B to
other people. |
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How does Entecavir work? |
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Baraclude is a
small-molecule guanosine nucleoside analog with selective
activity against hepatitis B virus (HBV) polymerase. The
drug is effectively phosporylated to the active triphosphate
form, which competes with the natural substrate
deoxyguanosine triphosphate, functionally inhibiting reverse
transription actions of HBV polymerase, including base
priming, negative strand DNA reverse transcription from RNA,
and synthesis of the positive strand of HBV DNA. The drug
produces only weak inhibition of normal cellular DNA
polymerases and mitochondrial DNA polymerase.
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Precautions Before Using Entecavir |
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Before
taking entecavir,
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tell your doctor
and pharmacist if you are allergic to entecavir, or any of
its ingredients, or any other medications. Ask your
pharmacist for a list of ingredients in entecavir.
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tell your doctor
and pharmacist what other prescription and nonprescription
medications, vitamins, nutritional supplements, and herbal
products you are taking or plan to take. Be sure to
mention the medications listed in the IMPORTANT WARNING
section and any of the following: aminoglycoside
antibiotics such as amikacin (Amikin), gentamicin (Garamycin),
kanamycin (Kantrex), neomycin (Neo-Rx, NeoFradin),
paramomycin (Humatin), streptomycin, and tobramycin (Tobi,
Nebcin); amphotericin B (Fungizone); aspirin and other
nonsteroidal anti-inflammatory medications (NSAIDs) such
as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn);
medications to prevent rejection of a transplanted organ
such as cyclosporine (Neoral, Sandimmune) or tacrolimus (Prograf);
probenecid; or vancomycin Your doctor may need to change
the doses of your medications or monitor you carefully for
side effects. |
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tell your doctor if
you have had a liver transplant (surgery to replace a
diseased liver), or if you have or have ever had kidney
disease. |
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tell your doctor if
you are pregnant, plan to become pregnant, or are
breast-feeding. If you become pregnant while taking
entecavir, call your doctor. Do not breastfeed while you
are taking entecavir. |
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if you are having
surgery, including dental surgery, tell the doctor or
dentist that you are taking entecavir. |
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Entecavir side effects |
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Entecavir may cause side effects. Tell your doctor if any of
these symptoms are severe or do not go away:
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headache
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dizziness
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diarrhea
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heartburn
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drowsiness
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difficulty falling
asleep or staying asleep |
Some
side effects can be serious. If you experience any of the
symptoms listed in the IMPORTANT WARNING section, call your
doctor immediately.
Entecavir may cause other side effects. Call your doctor if
you have any unusual problems while using this medication. |
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What should you do if you miss a dose of
Entecavir? |
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Take the
missed dose as soon as you remember it. However, if it is
almost time for the next dose, skip the missed dose and
continue your regular dosing schedule. Do not take a double
dose to make up for a missed one. |
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Entecavir Storage |
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Keep
this medication in the container it came in, tightly closed,
and out of reach of children and pets. Store it at room
temperature and away from excess heat, light, and moisture
(not in the bathroom). Throw away any medication that is
outdated or no longer needed by flushing the tablets down
the toilet or pouring the solution down the sink. Talk to
your pharmacist about the proper disposal of your
medication. |
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Disclaimer:
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Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
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