Cloprostenol Description
Cloprostenol is a synthetic prostaglandin analogue
of F2α for use in cattel, horses, and pigs.
Cloprostenol Storage
Store in a dark and dry place at 6-25C
Cloprostenol Pharmacological mechanism
Cloprostenol is a functional analogue of prostaglandin
F2α having a specific luteolytic action. It causes
functional and morphological regression of the corpus
luteum (luteolysis) in cattles and horses followed by
return to oestrus and normal ovulation.
Cloprostenol Indications
- Cloprostenol is recommended and specifically used in:
- Induction and synchronization of heat in heifers and
cows
- Synchronization of oestrus cycle in donor
- Recipient in the programs of embryo transfer in cattle
- Induction of farrowings in sows
- Treatment of functional disorders of ovaries
- Post-Partum and post service anoestrous
- Irregular and anovulatory cycles
- Persistent corpus luteum
- Luteal cysts
- Postpuerperal uterine disease
- Endometritis
- Pyometra
- Termination of normal or pathologic pregnancy at the
first half of gestation
- Follicular cysts on day 10th to 14th after
administration of LHRH or hCG
Cloprostenol Contra-indications, warnings
- Cloprostenol should not be administered to pregnant
animal unless the objective is to terminate the
pregnancy
- Cloprostenol can be absorbed through the skin and
therefor care should be taken when handling the product
especially by women of child-bearing age and by
asthmatics
- Accidental spillage on the skin should be washed off
immediately with water
- Cloprostenol may cause broncho-spasm in
man. Accidental inhalation or injection may cause a
rapid acting broncho-dilation
- Cloprostenol may cause peritonitis in the cases that
they are in pyometral condition with a stenosed
cervix
- Cloprostenol in horses may cause hyperrythmia and
colic with hyper hidrosis
