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Cefquinome
API |
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Haorui supplies high quality
Cefquinome
API produced by our
GMP facility that has been successfully inspected by the
FDA.
We offer
competitive prices and support our products with reliable technical and
regulatory services.
Cefquinome
API is available from R&D to
commercial quantities. Please contact us for more details. |
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The following
information is provided for general information purposes
ONLY. |
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What is Cefquinome? |
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Cefquinome (4GC) is a fourth generation
cephalosporin with pharmacological and antibacterial
properties valuable in the treatment of coliform mastitis
and other infections. It is used in the treatment of both
humans and animals. According to the Washington Post, it is
used as a last line of defence to keep humans alive. |
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Properties of Cefquinome
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Cefquinome is resistant to beta-lactamase.
Chemically, its zwitterionic structure can facilitate rapid
penetration across biological membranes, including porins of
bacterial cell wall. Plus, it has a higher affinity to
target penicillin binding proteins. Besides zwitterionic, it
is also made of beta-lactam nucleus, quaternary ammonium,
and aminothiazolyl moiety.
Cefquinome acts by inhibition of the cell wall synthesis,
but it has a relatively short half-life of about two and
half hours. It is less than 5% protein bound and is excreted
unchanged in the urine. |
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Intervet |
| Intervet developed cefquinome to treat bovine respiratory
disease, the most common disease in cattle. An injection,
containing 25mg cefquinome per ml, is given to cattle and
pigs. |
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Treatment |
In cattle, the injection should help against respiratory
disease caused by Mannheimia haemolytica and Pasteurella
multocida. It also helps with acute E. coli mastitis,
dermatitis, infectious ulbar necrosis, and interdigital
necrobacillosis (which is foul in the foot). In calves, it
is E. coli septicaemia.
For pigs, it would treat the bacterial infections of the
lungs and respiratory tract caused by P. multocida,
Haemophilus parasuis, Actinobacillus pleuropneumoniae, and
Streptococcus suis. Mastitis-Metritis-Agalactia Syndrom (MMA)
involved with E. coli, Staphylococcus, Streptococcus, and
other cefquinome-sensitive organisms will also be treated.
In piglets, the mortality rate in cases of meningitis caused
by Streptococcus suis is reduced. It is used in the
treatment of mild or moderate lesions caused by
Staphylococcus hyicus and arthritis caused by Streptococcus
and E. coli. |
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Usage |
Shake the vial well before using.
Swab the septum before removing each dose. Use a dry sterile
needle and syringe. An appropriately graduated syringe must
be used to allow accurate administration of the required
dose volume. This is particularly important when injecting
small volumes, for example when treating piglets. The cap
may be safely punctured up to 25 times. The 50 ml vial
should be used for treating small piglets. When treating
groups of animals, use a draw-off needle. |
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Caution/Warnings |
These are some factors to be aware of before treating.
This product should not be used in animals known to be
hypersensitive to ¦Â-lactam antibiotics.
Should not be administer to animals with a bodyweight less
than 1.25kg.
Use of the product may result in localised tissue reaction.
Tissue lesions are repaired by 15 days after the last
administration of the product.
Hypersensitivity reactions to cephalosporins occur rarely.
The product does not contain an antimicrobial preservative.
To prevent the claimed infections in piglets, attention
should be paid to hygiene and ventilation, and overcrowding
should be avoided. When the first piglets are affected,
careful examination of all animals in the same pen is
recommended to enable an early treatment of any other
infected piglets. |
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Human Use |
| The only 4GC approved in US for human use is Maxipime (cefepime
HCI). There are two main reasons for cefepime¡¯s primary use
in human medicine. For one, cefepime is the only agent
approved for empiric monotherapy for neutropenic fever. The
other reason is that cefepime is used to treat enteric
pathogens of non-food-borne-disease. |
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Veterinary
Medicine |
Conditions of use are limited to therapeutic, parenteral,
and individual animal use. Individual parental therapy of
bovine respiratory disease data on cefquinome-related
residues demonstrate that only very small amounts are
present in the intestinal tract of treated cattle with
gastro-intestinal activation.
However, treatment should be short, meaning a single
injection daily for about a week. Treatment should only be
given by prescription. Cefquinome should not be used in
feeding and water.
Since 1994, in Europe, it was allowed to treat cattle by
prescription only. In 1999, swines were included. By 2005,
horses were allowed as well.
In the United States, the situation is pending for treatment
of bovine respiratory disease. Even so, this is only
available by prescription.
Cefquinome are also used for other illnesses, such as
¡°shipping fever,¡± a pneumonia-like illness commonly found in
cows |
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Disclaimer:
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Information on this page is provided for
general information purposes. You should not make a clinical
treatment decision based on information contained in this
page without consulting other references including the
package insert of the drug, textbooks and where relevant,
expert opinion. We cannot be held responsible for any errors
you make in administering drugs mentioned on this page, nor
for use of any erroneous information contained on this
page. |
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