Alvespimycin HCl API

Haorui supplies high quality Alvespimycin HCl API produced by our GMP facility that has been successfully inspected by the FDA. We offer competitive prices and support our products with reliable technical and regulatory services. Alvespimycin HCl API is available from R&D to commercial quantities. Please contact us for more details.

The following information is provided for general information purposes ONLY.

 

Alvespimycin HCl Description The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Chemical Structure Alvespimycin HCl Chemical structure names - 17-dimethylaminoethylamino-17-demethoxygeldanamycin - geldanamycin,17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-,monohydrochloride - hydrochloride of (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[[2-(dimethylamino)ethyl]amino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-penten-9-yl carbamate.

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